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The drug is believed to work by inhibiting dopamine uptake, leading to increased dopamine levels in the brain. It should account for increases in motivation, wakefulness and other aspects of cognition after taking the drug. It’s also been speculated that modafinil increases levels of histamines in the brain to generate some of these effects, having an opposite effect of hayfever tablets, which usually contain antihistamines. Its exact method of action is not fully known.
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